The CD274 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to CD274. This antibody recognizes Human, Mouse, and Rat antigen. The CD274 Antibody has been validated for the following applications: ELISA, Immunohistochemistry, and Western Blot.
Description
Description: Programmed cell death ligand 1(CD274, or B7-H1, PD-L1), is the first member of B7 family to be discovered. B7 family molecules are type I transmembrane proteins belonging to the immunoglobulin superfamily. In concert with their CD28 family receptors, the B7s are key regulators of the adaptive immune response. CD274 is suggested a negative regulator of T and B cell, and play important role in mediating tolerance of lymphocytes to self-antigens. It also involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner.
Function: Plays a critical role in induction and maintenance of immune tolerance to self. As a ligand for the inhibitory receptor PDCD1/CD279, modulates the activation threshold of T-cells and limits T-cell effector response (PubMed:11015443). The PDCD1/CD279-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and facilitate tumor survival (PubMed:28813417, PubMed:28813410). Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10) (PubMed:10581077).
Subunit Structure: Interacts with PDCD1 (PubMed:11015443, PubMed:18287011). Interacts (via transmembrane domain) with CMTM4 and CMTM6 (PubMed:28813417, PubMed:28813410).
Post-translational Modifications: Ubiquitinated; STUB1 likely mediates polyubiquitination of PD-L1/CD274 triggering its degradation.
Similarity: Belongs to the immunoglobulin superfamily. BTN/MOG family